• Plast. Reconstr. Surg. · Jul 2013

    Randomized Controlled Trial Comparative Study

    Prospective randomized controlled trial: fibrin sealant reduces split skin graft donor-site pain.

    • Ciaran Healy, Aina V H Greig, Adrian D Murphy, Christopher Powell, Richard J Pinder, Samer Saour, Christopher Abela, William Knight, and Jenny L C Geh.
    • Department of Plastic Surgery, St. Thomas' Hospital, and the School of Public Health, Imperial College London, St. Mary's Hospital, London, United Kingdom. ciaran.healy@gstt.nhs.uk
    • Plast. Reconstr. Surg. 2013 Jul 1;132(1):139e-46e.

    BackgroundPain at split skin graft donor sites is common. Fibrin sealant has been demonstrated to reduce time to hemostasis at wound sites, and patients receiving this treatment were incidentally noted to report less pain. This study aimed to evaluate pain and incapacity in split skin graft donor sites treated with and without fibrin sealant.MethodsFifty patients requiring thigh donor-site split skin grafts were prospectively randomized to receive either a self-adhesive fabric dressing alone or fibrin sealant plus the self-adhesive fabric dressing as primary donor-site dressings. External secondary dressings were the same. Patients were blinded with regard to treatment group. Using visual analogue scales (scored 0 to 5), patients rated their donor-site pain and incapacity for 14 days postoperatively. Secondary endpoints were length of hospital stay and duration of requirement for dressings.ResultsForty patients were included in the study analysis and completed self-reported pain and incapacity scores. Twenty received the fibrin sealant plus self-adhesive fabric dressing and 20 received the fabric dressing only (controls). Patients using the fibrin sealant plus the dressing reported significantly less pain (mean score, 0.42 versus 1.60, p < 0.001) and significantly less incapacity (mean score, 0.48 versus 1.71, p < 0.001). Patients allocated to the fibrin sealant group recorded shorter lengths of stay and faster time to discontinuation of dressing, though statistical significance was not achieved.ConclusionPatients whose split skin graft donor sites were dressed with fibrin sealant plus self-adhesive fabric dressing experienced significantly less pain and incapacity than patients with self-adhesive fabric dressings alone, allowing a more rapid return to normal activity.Clinical Question/Level Of EvidenceTherapeutic, II.

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