• J. Neurosci. · Nov 1999

    A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses.

    • C C Huang, Y C Liang, and K S Hsu.
    • Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan City, Taiwan 70101.
    • J. Neurosci. 1999 Nov 15;19(22):9728-38.

    AbstractThe involvement of adenosine on the development of time-dependent reversal of long-term potentiation (LTP) by low-frequency stimulation (LFS) was investigated at Schaffer collateral-CA1 synapses of rat hippocampal slices. A train of LFS (2 Hz, 10 min, 1200 pulses) had no long-term effects on synaptic transmission but produced lasting depression of previously potentiated responses. This reversal of LTP (depotentiation) was observed when the stimulus was delivered

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