• Behav. Brain Res. · Nov 2011

    β1-noradrenergic system of the central amygdala is involved in state-dependent memory induced by a cannabinoid agonist, WIN55,212-2, in rat.

    • Maryam Ghiasvand, Ameneh Rezayof, Shamseddin Ahmadi, and Mohammad-Reza Zarrindast.
    • Institute for Cognitive Science Studies, Tehran, Iran.
    • Behav. Brain Res. 2011 Nov 20;225(1):1-6.

    AbstractIn the present study, we investigated effects of intra-central amygdala (intra-CeA) administrations of a β1-receptor agonist and antagonist, isoprenaline (isoproterenol) and atenolol respectively, on state-dependent memory induced by a cannabioid agonist, WIN55,212-2. This study used a step-through inhibitory avoidance task to assess memory in male Wistar rats. The results showed that post-training intra-CeA administrations of different doses of WIN55,212-2 (0.01, 0.05, 0.1 and 0.25μg/rat) decreased memory as revealed by a decrease in memory retrieval on the test day. The decrease in retrieval induced by post-training WIN55,212-2 (0.25μg/rat) was reversed by pre-test administration of the same dose of the drug, which was suggestive of drug-induced state-dependent memory. Although pre-test intra-CeA administrations of isoprenaline (0.01, 0.025 and 0.05μg/rat) alone had no effect, its co-administrations at doses of 0.025 and 0.05μg/rat with an ineffective dose of WIN55,212-2 (0.1μg/rat) restored memory retrieval that impaired by post-training WIN55,212-2 (0.25μg/rat). The results also showed that pre-test intra-CeA administrations of atenolol (0.01, 0.05 and 0.1μg/rat) alone had no effect, but at dose of 0.1μg/rat disrupted state-dependent memory induced by WIN55,212-2. Moreover, the improving effect of isoprenaline (0.025μg/rat) on retrieval of state-dependent memory induced by WIN55,212-2 (0.1μg/rat) was prevented by intra-CeA co-injections of atenolol. Taken together, our results suggest that the CeA may be potentially critical for state-dependent memory induced by WIN55,212-2 and the β1-noradrenergic receptor mechanism(s) interact with the cannabinergic system in the modulation of this kind of memory in the CeA.Copyright © 2011 Elsevier B.V. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…