• Arch Iran Med · Nov 2011

    Modulation of WIN55,212-2 state-dependent memory by α2-adrenergic receptors of the dorsal hippocampus.

    • Morteza Piri and Mohammad-Reza Zarrindast.
    • Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Ardabil Branch, Ardabil, Iran.
    • Arch Iran Med. 2011 Nov 1; 14 (6): 389-95.

    BackgroundAn overlapping distribution of α2-adrenergic receptors with cannabinoid receptors has been reported in certain brain structures such as the dorsal hippocampus. Thus, functional interactions between cannabinoid and α2-adrenergic systems in cognitive control seem possible. In the present study, we examine the possible role of α2-adrenergic receptors of the dorsal hippocampus on WIN55,212-2 state-dependent learning.MethodsAdult male Wistar rats were bilaterally implanted with chronic cannulae in the CA1 regions of their dorsal hippocampi trained in a step-down type inhibitory avoidance task and tested 24 hr after training, to measure step-down latency.ResultsPost-training or pre-test intra-CA1 administration of the cannabinoid receptor agonist, WIN 55,212-2 (0.25 and 0.5 µg/rat) induced amnesia. Amnesia produced by post-training WIN55,212-2 (0.5 µg/rat) was reversed by pre-test administration of WIN55,212-2, that was due to a state-dependent effect. Pre-test intra-CA1 microinjections of clonidine (0.25, 0.5 and 1 μg/rat) or yohimbine (0.5, 0.75, and 1 μg/rat) did not affect memory retrieval per se. Pre-test intra-CA1 administration of clonidine (0.5 and 1 μg/rat) or clonidine (0.25, 0.5, and 1 μg/rat) with an ineffective dose of WIN 55,212-2 (0.25 µg/rat) reversed post-training WIN55,212-2 (0.5 µg/rat,intra-CA1) induced memory impairment. Pre-test intra-CA1 microinjection of yohimbine (1 μg/rat) before administration of WIN55,212-2 (0.5 µg/rat, intra-CA1), however, dose-dependently inhibited WIN55,212-2 state-dependent memory.ConclusionModulation of α2-adrenergic receptors in the dorsal hippocampal CA1 regions can influence WIN55,212-2 induced amnesia and WIN55,212-2 state-dependent learning of an inhibitory avoidance task by pre- or post-synaptic mechanism(s).

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.