• Alexander Zlotnik, Benjamin F Gruenbaum, Akiva Leibowitz, Sharon Ohayon, Matthew Boyko, Yoram Shapira, Boris Rogachev, Amit Saad, Victoria Vorobiovsky, Alla Shnaider, Moshe Zlotnik, and Abed N Azab.
• Department of Nephrology, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva, Israel.
• J Crit Care. 2012 Dec 1;27(6):743.e1-7.

PurposeThe purpose of the present study is to investigate whether hemodialysis (HD) is effective in lowering blood glutamate levels. In addition, we examined the effect of HD on glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels in the blood and described the rate and pattern of blood glutamate clearance during HD.Materials And MethodsBlood samples were taken from 45 patients with stage V chronic kidney disease immediately after initiation of HD and hourly, for a total of 5 blood samples. Samples were sent for determination of glutamate, glucose, GOT, GPT, hemoglobin, hematocrit, urea, and creatinine levels. A blood sample from 25 healthy volunteers without chronic renal failure was used as a control for the determination of baseline blood levels of glutamate, GOT, and GPT.ResultsGlutamate and GPT levels in patients on HD were higher at baseline compared with healthy controls (P < .001). In the first 3 hours after HD, there was a decrease in blood glutamate levels compared with baseline levels (P < .00001). At the fourth hour, there was an increase in blood glutamate levels compared with the third hour (P < .05).ConclusionsHemodialysis may be a promising method of reducing blood glutamate levels.Copyright © 2012 Elsevier Inc. All rights reserved.

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