• Clin. Infect. Dis. · Aug 2015

    Case Reports

    The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States.

    • Colleen S Kraft, Angela L Hewlett, Scott Koepsell, Anne M Winkler, Christopher J Kratochvil, LuAnn Larson, Jay B Varkey, Aneesh K Mehta, G Marshall Lyon, Rachel J Friedman-Moraco, Vincent C Marconi, Charles E Hill, James N Sullivan, Daniel W Johnson, Steven J Lisco, Mark J Mulligan, Timothy M Uyeki, Anita K McElroy, Tara Sealy, Shelley Campbell, Christina Spiropoulou, Ute Ströher, Ian Crozier, Richard Sacra, Michael J Connor, Viranuj Sueblinvong, Harold A Franch, Philip W Smith, Bruce S Ribner, and Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unit.
    • Department of Pathology and Laboratory Medicine Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
    • Clin. Infect. Dis. 2015 Aug 15; 61 (4): 496-502.

    BackgroundThe current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.MethodsWe report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma.ResultsWhile one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.ConclusionsIt is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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