• Christoph Nau, Sebastian Wutzler, Hagen Dörr, Mark Lehnert, Rolf Lefering, Helmut Laurer, Hendrik Wyen, Ingo Marzi, and Trauma Registry of DGU.
• Department of Trauma, Hand and Reconstructive Surgery, Hospital of the Johann Wolfgang, Goethe-University, Frankfurt, Germany. christoph.nau@kgu.de
• Injury. 2013 May 1;44(5):661-6.

IntroductionLiver cirrhosis has been shown to be associated with impaired outcome in patients who underwent elective surgery. We therefore investigated the impact of alcohol abuse and subsequent liver cirrhosis on outcome in multiple trauma patients.Materials And MethodsUsing the multi-centre population-based Trauma Registry of the German Society for Trauma Surgery, we retrospectively compared outcome in patients (ISS ≥ 9, ≥ 18) with pre-existing alcohol abuse and liver cirrhosis with healthy trauma victims in univariate and matched-pair analysis. Means were compared using Student's t-test and analysis of variance (ANOVA) and categorical variables using χ(2) (p<0.05=significant).ResultsOverall 13,527 patients met the inclusion criteria and were, thus, analyzed. 713 (5.3%) patients had a documented alcohol abuse and 91 (0.7%) suffered from liver cirrhosis. Patients abusing alcohol and suffering from cirrhosis differed from controls regarding injury pattern, age and outcome. More specific, liver cirrhotic patients showed significantly higher in-hospital mortality than predicted (35% vs. predicted 19%) and increased single- and multi-organ failure rates. While alcohol abuse increased organ failure rates as well this did not affect in-hospital mortality.ConclusionsPatients suffering from liver cirrhosis presented impaired outcome after multiple injuries. Pre-existing condition such as cirrhosis should be implemented in trauma scores to assess the individual mortality risk profile.Copyright © 2012 Elsevier Ltd. All rights reserved.

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