• Katalin Sándor, Krisztián Elekes, Arpád Szabó, Erika Pintér, Mia Engström, Siegfried Wurster, János Szolcsányi, and Zsuzsanna Helyes.
• Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs-7624 Szigeti str. 12, Hungary.
• Eur. J. Pharmacol. 2006 Jun 6;539(1-2):71-5.

AbstractSomatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 microg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy.

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