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- R A Mafra, S G Figueiredo, C R Diniz, M N Cordeiro, J D Cruz, and M E De Lima.
- Departamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte-MG, Brazil.
- Brain Res. 1999 Jun 12;831(1-2):297-300.
AbstractWe report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2.35+/-0.9 microg/ml which is in the observed range reported for glutamate uptake blockers. Tx4-7, one of PhTx4 toxins, showed the strongest inhibitory activity (50.3+/-0.69%, n=3).Copyright 1999 Elsevier Science B.V.
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