• Nan Fang Yi Ke Da Xue Xue Bao · May 2010

    Randomized Controlled Trial

    [Effects of etomidate infusion on serum cortisol in patients undergoing radical resection of lung cancer].

    • Yong-qiu Xie, He-na Jiao, Qu-lian Guo, and Chan Cheng.
    • Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. yongqiuxie@yahoo.com.cn
    • Nan Fang Yi Ke Da Xue Xue Bao. 2010 May 1;30(5):1047-9.

    ObjectiveTo evaluate the effect of etodimate infusion on serum cortisol in patients undergoing radical resection of lung cancer operations during the perioperative period.MethodsForty ASA I-II patients undergoing radical resection of lung cancer were randomly divided into etomidate group (Group E) and propofol group (Group P) (n=20). The serum cortisol was measured at 8:00 am (T(0)) before anesthesia, 4:00 pm (T(1)) on the day of operation and 24 h after the operation (T(2)) by radioimmunoassay.ResultsCompared with that at T0, the serum level of cortisol significantly increased at 24 h after the operation in both groups (P<0.01); serum cortisol decreased lightly at T1, which was not statistically significant (P>0.05), and remained higher than the normal level. At each of the time points, serum cortisol levels were comparable between the two groups (P>0.05).ConclusionEtomidate infusion can not inhibit the synthesis of cortisol in patients undergoing radical resection of lung cancer.

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