• Mult. Scler. · Feb 2014

    Randomized Controlled Trial Multicenter Study

    Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study.

    • Mariko Kita, Robert J Fox, J Theodore Phillips, Michael Hutchinson, Eva Havrdova, Sujata P Sarda, Sonalee Agarwal, Jessica Kong, Annie Zhang, Vissia Viglietta, Sarah I Sheikh, Emily Seidman, and Katherine T Dawson.
    • Neuroscience Institute, Virginia Mason Medical Center, Seattle, WA, USA.
    • Mult. Scler. 2014 Feb 1;20(2):253-7.

    AbstractMultiple sclerosis (MS) has a significant impact on health-related quality of life (HRQoL) with symptoms adversely affecting many aspects of everyday living. BG-12 (dimethyl fumarate) demonstrated significant efficacy in the phase III studies DEFINE and CONFIRM in patients with relapsing-remitting MS. In CONFIRM, HRQoL was worse in patients with greater disability at baseline, and who relapsed during the study, and improved with BG-12 treatment. Mean Short Form-36 Physical Component Summary scores for BG-12 increased over 2 years and scores for placebo decreased. Coupled with clinical and neuroradiological benefits, these HRQoL results further support BG-12 as an effective oral treatment for relapsing MS.

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