• D'Anne Neal and James A Lin.
• Department of Pediatrics, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA.
• Pediatr Crit Care Me. 2009 Sep 1;10(5):592-6.

ObjectiveTo determine the effect of syringe size on safety and reliability of low-flow infusions at rates relevant to hemodynamically unstable infants.Design: In vitro study using readily available clinical equipment.SettingMedical-surgical pediatric intensive care unit of a university-affiliated hospital.Patients/SubjectsNone.InterventionsThree-, 12-, and 60-mL syringes (Kendall Monoject) with extension tubing were mounted in identical Baxter AS50 infusion pumps. We determined time to alarm after occlusion of the distal tubing. We described and validated a method using capillary tubes to determine startup time to reach steady-state flow and variability of steady-state flow. Data were analyzed using single-factor analysis of variance or linear regression, as appropriate.Measurements And Main ResultsAt 5 mL/hr flow, time to alarm occlusion (mean +/- sd) was 1:08 +/- 0:42, 3:35 +/- 0:58, and 27:06 +/- 3:26 minutes for 3-, 12-, and 60-mL syringes, respectively (p < .00001). At a lower flow of 0.2 mL/hr, none of the pumps alarmed despite 30 mins of distal occlusion, regardless of syringe size. Validation testing of the capillary tube volumetric method revealed a sd <5% of the average fluid column displacement. Startup time to reach steady-state flow of 0.2 mL/hr for 60-mL syringes was 76 +/- 40 mins and significantly exceeded 24 +/- 10 mins for 3-mL syringes (p = .041). In one test using a 60-mL syringe, flow remained below 20% of steady state for >3 hrs. Average steady-state flow was similar for the three syringe sizes (p = .2861), but sd of steady-state flow was directly related to syringe size and regressed to a line with r = 1.ConclusionsSyringe size is related to time to reach steady-state flow, time to alarm occlusion, and variability of low-flow infusions.

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