• Pablo Cardinal-Fernández, Antonio Ferruelo, Mariam El-Assar, Catalina Santiago, Félix Gómez-Gallego, Ana Martín-Pellicer, Fernando Frutos-Vivar, Oscar Peñuelas, Nicolás Nin, Andrés Esteban, and José A Lorente.
• Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Madrid, Spain.
• J Crit Care. 2013 Aug 1;28(4):365-70.

PurposeThe aim of this study was to demonstrate that candidate gene polymorphisms are associated with an increased risk of acute kidney injury (AKI).Materials And MethodsPatients admitted to the intensive care unit with the diagnosis of severe sepsis and an expected intensive care unit length of stay more than 48 hours were included. Genetic polymorphisms studied included angiotensin-converting enzyme insertion/deletion (polymerase chain reaction); tumor necrosis factor α -376, - 308, and -238; interleukin-8 -251; vascular endothelial growth factor (VEGF) +405 and +936; and pre-B-cell colony-enhancing factor -1001 (TaqMan SNP genotyping assay, Life Technologies, Grand Island, NY). Acute kidney injury was defined as the risk, injury, and failure categories, as per the RIFLE (risk, injury, failure, loss, end-stage kidney disease) classification.ResultsOne hundred thirty-nine patients were included, 65 of whom developed AKI. In univariate analysis, the VEGF +936 CC and the pre-B-cell colony-enhancing factor -1001 GG genotypes were associated with AKI. In multivariate analysis, Simplified Acute Physiology Score II score (odds ratio [95% confidence interval], 1.06 [1.03-1.09]), chronic arterial hypertension (3.15 [1.39-7.15]), and the presence of the VEGF +936 CC genotype (3.41 [1.19-9.79]) were associated with AKI.ConclusionThis is the first study demonstrating an association between the VEGF +936 CC genotype and the risk to develop AKI in patients with severe sepsis.Copyright © 2013 Elsevier Inc. All rights reserved.

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