• C Wiesenack, C Prasser, C Keyl, and G Rödīg.
• Department of Anaesthesia, University Hospital, Regensburg, Germany. wiesenack@rhananw1/ngate/uni-regensburg.de
• J. Cardiothorac. Vasc. Anesth. 2001 Oct 1;15(5):584-8.

ObjectiveTo analyze the clinical value of a new device (PiCCO) for cardiac output measurement and volume preload parameter assessment, based on transpulmonary thermodilution technique, as an alternative to the pulmonary artery thermodilution technique and assessment of pressure preload parameters derived from the pulmonary artery catheter.DesignProspective, controlled, clinical study.SettingUniversity hospital.ParticipantsEighteen patients with ejection fraction >50% undergoing coronary artery bypass graft surgery.InterventionsA baseline measurement was performed after induction of anesthesia under clinical steady-state conditions (T1). Hypovolemia, defined as central venous pressure (CVP) <10 mmHg and pulmonary capillary wedge pressure (PCWP) <12 mmHg, was treated by infusion of 6% hydroxyethyl starch 200/0.5 (7 mL/kg). After 10 minutes, a second measurement (T2) was performed.Measurements And Main ResultsThe mean difference (bias) between transpulmonary thermodilution cardiac output and pulmonary artery thermodilution cardiac output did not differ at the 2 sample points. Changes in pressure preload parameters of the pulmonary artery catheter (CVP, PCWP) did not correlate with changes in cardiac output or stroke volume, whereas changes in volume preload parameter intrathoracic blood volume (ITBV) of the PiCCO correlated significantly with changes in cardiac output and stroke volume (r = 0.55, p < 0.05; r = 0.62, p < 0.01).ConclusionThese results suggest that increased cardiac preload is more reliably reflected by ITBV than by CVP or PCWP. The assessment of ITBV by the transpulmonary single indicator dilution technique is an interesting alternative to the pressure preload parameters.Copyright 2001 by W.B. Saunders Company

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