• Louise Pape Larsen, Klaus Veng Kristensen, and Hans Kirkegaard.
• Aarhus Universitet, Det Sundhedsvidenskabelige Fakultet og Arhus Universitetshospital, Skejby.
• Ugeskr. Laeg. 2009 Apr 20;171(17):1392-6.

IntroductionThe objective of the present paper was to examine the association between cerebral status at discharge in patients treated with therapeutic hypothermia (TH) and: 1) time form collapse to initiation of TH, 2) time form collapse to target temperature (32-34 degrees C), 3) time from initiation of TH to target temperature and 4) time to awakening after attainment of normal temperature. We also investigated the significance of age, over and under 70, and precipitating arrhythmia in relation to cerebral status at discharge.Material And MethodsA total of 55 resuscitated but continuously comatose cardiac arrest patients who had received TH.Outcome Measurescerebral status at discharge and 30-day mortality.ResultsNo significant association was found between cerebral score at discharge and 1) time span from collapse to initiation of TH, 2) time form collapse to target temperature or 3) time from initiation of TH to target temperature. It was found, however, that a longer time to awakening after attainment of normal temperature was associated with a poorer cerebral outcome (p = 0.000). There is a non-significant tendency towards a worse cerebral outcome and higher 30-day mortality in patients aged over 70 years, and in patients with asystole as precipitating arrhythmia.ConclusionAmong the factors investigated, only time from attainment of normal body temperature to awakening was significantly associated with cerebral outcome.

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