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Meta Analysis
An association study between genetic polymorphism in the interleukin-6 receptor gene and coronary heart disease.
- Jiangqing Zhou, Xiaoliang Chen, Huadan Ye, Ping Peng, Yanna Ba, Xi Yang, Xiaoyan Huang, Yae Lu, Xin Jiang, Jiangfang Lian, and Shiwei Duan.
- Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
- Biomed Res Int. 2014 Jan 1;2014:504727.
AbstractThe goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese (P > 0.05). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans (P < 0.0001, odds ratio = 0.93, 95% confidential interval = 0.89-0.96). Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.
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