• Kate Jackson, Michael Ashby, Deb Howell, Jennifer Petersen, David Brumley, Phillip Good, Maria Pisasale, Simon Wein, and Roger Woodruff.
• Supportive and Palliative Care Unit, Southern Health and Monash University, and McCulloch House PCU, Monash Medical Centre, Locked Bag 29, Clayton South, Victoria 3169, Australia. kate.jackson@southernhealth.org.au
• J Palliat Care. 2010 Jan 1;26(3):176-83.

AbstractThis multi-centre study of adjuvant "burst" ketamine in palliative care in-patients documents its effectiveness, duration of pain relief, and adverse effects (AE) profile. Patients received a three-to-five day continuous subcutaneous infusion (CSCI) of ketamine escalated from 100 to 300 to 500 mg/24 hours if required. When the effective or maximum tolerated dose was attained, the infusion was continued for three days and each patient assessed as a responder or non-responder using strict criteria. The response rate was 22/44 (50 percent), with 4 (9 percent) becoming pain-free. Pain relief lasting two or more weeks was documented in 50 percent of responders. AEs were documented daily using the National Cancer Institute (NCI) Common Toxicity Criteria 0-4 scales. There were 11 grade 3 and 4 neurological AEs. However, no responders elected to cease treatment early due to neurological AEs. We concluded that this protocol in the controlled environment of an in-patient PC unit is relatively safe and simple with reasonable effectiveness.

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