• Ary Serpa Neto, Sérgio O Cardoso, David S Y Ong, Daniel C Espósito, Victor G M Pereira, José A Manetta, Arjen J C Slooter, and Olaf L Cremer.
• Department of Critical Care Medicine, ABC Medical School (FMABC), Santo André, Brazil; Department of Critical Care Medicine, Hospital Israelita Albert Einstein (HIAE), São Paulo, Brazil. Electronic address: aryserpa@terra.com.br.
• J Crit Care. 2013 Oct 1;28(5):681-6.

PurposeOur aims were to determine whether the pulse oximetric saturation/fraction of inspired oxygen (S/F) can be used for the early identification of patients with sepsis who are at increased risk for death and to compare the S/F ratio with the Pao2/fraction of inspired oxygen (P/F) ratio.Materials And MethodsThis is a retrospective cohort study in 260 patients admitted to 2 tertiary mixed intensive care units (ICUs) with severe sepsis or septic shock. We studied the association between tertiles of S/F ratio and ICU mortality using Cox regression. Subsequently, we compared corresponding measurements of S/F ratio and P/F ratio upon ICU admission using Pearson correlation coefficient (r).ResultsWe observed an overall case fatality of 72 (28%) of 260. After adjustment for severity of the illness, the lowest tertile (S/F, <164) at ICU admission was associated with increased mortality (hazard ratio, 1.87 [95% confidence interval, 1.02-3.41]) comparing to the highest tertile (S/F, >236). The S/F ratio was correlated with P/F ratio (r=0.48; P<.0001).ConclusionA low S/F at ICU admission is associated with increased risk of death in patients with severe sepsis or septic shock.Copyright © 2013 Elsevier Inc. All rights reserved.

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