• Curr Med Res Opin · Oct 2006

    Editorial Comment

    Ezetimibe/simvastatin single tablet versus rosuvastatin in patients with hypercholesterolemia.

    • Stella S Daskalopoulou and Dimitri P Mikhailidis.
    • Curr Med Res Opin. 2006 Oct 1;22(10):2037-9.

    AbstractRecent guidelines recommend strict goals for low density lipoprotein cholesterol (LDL-C) (70-100 mg/dL; 1.8-2.6 mmol/L). These goals were set following the publication of several trials. In the current issue of the journal, a study compares different doses of the combination tablet (ezetimibe/simvastatin) with statin monotherapy (rosuvastatin). In keeping with previous literature, the combination therapy was more effective in achieving LDL-C goals. This editorial comments on the potential disadvantages of using monotherapy with high-dose statins and considers the issue of statin-induced proteinuria. Combination therapy may need to be increasingly used to achieve the LDL-C targets set by recent guidelines.

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