• Sam M Doesburg, Alexander Moiseev, Anthony T Herdman, Urs Ribary, and Ruth E Grunau.
• Department of Diagnostic Imaging, The Hospital for Sick Children , Toronto, ON , Canada ; Neurosciences & Mental Health Program, Research Institute, The Hospital for Sick Children , Toronto, ON , Canada ; Department of Medical Imaging, University of Toronto , Toronto, ON , Canada ; Department of Psychology, University of Toronto , Toronto, ON , Canada.
• Front Hum Neurosci. 2013 Jan 1;7:791.

AbstractChildren born very preterm (≤32 weeks gestational age) without major intellectual or neurological impairments often express selective deficits in visual-perceptual abilities. The alterations in neurophysiological development underlying these problems, however, remain poorly understood. Recent research has indicated that spontaneous alpha oscillations are slowed in children born very preterm, and that atypical alpha-mediated functional network connectivity may underlie selective developmental difficulties in visual-perceptual ability in this group. The present study provides the first source-resolved analysis of slowing of spontaneous alpha oscillations in very preterm children, indicating alterations in a distributed set of brain regions concentrated in areas of posterior parietal and inferior temporal regions associated with visual perception, as well as prefrontal cortical regions and thalamus. We also uniquely demonstrate that slowing of alpha oscillations is associated with selective difficulties in visual-perceptual ability in very preterm children. These results indicate that region-specific slowing of alpha oscillations contribute to selective developmental difficulties prevalent in this population.

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