• Murat Dizbay, Gülbin Aygencel, Melda Türkoğlu, Ayşe Fitnat Tuncel, Burcu Arslan Candır, Yelda Deligöz Bildacı, and Hatice Paşaoğlu.
• Medical Intensive Care Unit, Gazi University School of Medicine, Ankara, Turkey. Electronic address: meldaturkoglu@yahoo.com.tr.
• J Crit Care. 2013 Oct 1;28(5):735-40.

PurposeA growing number of evidence demonstrates deficiency of vitamin D in critically ill patients. We aimed to evaluate the vitamin D status of our critically ill patients and its relevance to infections in these patients.Material And MethodsWe conducted a prospective observational study in 201 critically ill patients admitted to the medical intensive care unit of Gazi University Hospital between October 2009 through March 2011.ResultsSixty-nine percent of the patients were found to be vitamin D deficient. Infection rate was higher in the deficient group, though without statistical significance (P=.117). Infections with Acinetobacter baumannii was significantly more frequent in patients with Vitamin D deficiency (25% vs 10%, P=.012). The median level of 25-hydroxyvitamin D levels was 11.8 [6.3-17.2] ng/mL and 15.7 [8.1-28.9] ng/mL in patients with and without A baumannii infections respectively (P=.024). Logistic regression analysis demonstrated that vitamin D deficiency (P=.042) and invasive mechanical ventilation (P=.001) were the 2 independent risk factors in the development of A baumannii infections, in addition.ConclusionsVitamin D deficiency is common in critically ill patients. Even though there was no statistical difference between vitamin D deficient and sufficient patients regarding development of infections in general, A baumannii infections were significantly more frequent in the deficient group. Vitamin D deficiency was found as one of the independent risk factors for A baumannii infections. Further multicenter studies with a larger sample size are required to validate our data.Copyright © 2013 Elsevier Inc. All rights reserved.

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