• J Invest Allerg Clin · Jan 2009

    Case Reports

    Nine cases of omeprazole allergy: cross-reactivity between proton pump inhibitors.

    • T Lobera, B Navarro, M D Del Pozo, I González, A Blasco, R Escudero, M Venturini, and E Alarcón.
    • Department of Allergy, Hospital San Pedro/San Millán, Logroño, Spain. tlobera@riojasalud.es
    • J Invest Allerg Clin. 2009 Jan 1;19(1):57-60.

    AbstractAlthough rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole. Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Skin prick tests and oral controlled challenge tests with omeprazole, lansoprazole, and pantoprazole were performed. Skin prick or intradermal tests with omeprazole were positive in 8 patients. Four were also positive to pantoprazole. Prick tests with lansoprazole were always negative. Lansoprazole was administered to all 9 patients, with good tolerance in 8. Only 3 patients were challenged with pantoprazole and developed widespread urticaria. We present 9 patients with immunoglobulin E-mediated allergy to omeprazole. In most of our cases, lansoprazole proved to be a good alternative treatment.

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