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Case Reports
Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism?
- A G A Brouwers and C M J A Waals-van de Wal.
- Department of Paediatric Intensive Care, Academic Hospital Maastricht, P. Debyelaan 25, Maastricht, The Netherlands. A.Brouwers@mumc.nl
- Acta Paediatr. 2009 Jun 1;98(6):1064-5.
AbstractNitric oxide (NO) is an important mediator of biological functions. Absence or shortage of NO plays a role in the pathogenesis of both hypertrophic pyloric stenosis and persistent pulmonary hypertension. We present a neonate diagnosed with pulmonary hypertension after birth caused by meconium-aspiration syndrome eventually treated with extracorporal membrane oxygenation followed by hypertrophic pyloric stenosis for which a pyloromyotomy was performed. In conclusion, the association of pulmonary hypertension and pyloric stenosis has not been described before and may be explained by a lowered plasma concentration of arginine leading to deficient NO synthesis in the affected organ systems.
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