• Suelene Aires Franca, Carlos Toufen, André Luiz D Hovnanian, André Luís P Albuquerque, Eduardo R Borges, Vladimir R P Pizzo, and Carlos Roberto Ribeiro Carvalho.
• Pulmonary Division, InCor, University of São Paulo Medical School, São Paulo, Brazil 05403-900.
• J Crit Care. 2011 Jun 1;26(3):330.e1-8.

PurposeThe purpose of this study was to assess risk factors associated with the development of acute respiratory failure (ARF) and death in a general intensive care unit (ICU).Materials And MethodsAdults who were hospitalized at 12 surgical and nonsurgical ICUs were prospectively followed up. Multivariable analyses were realized to determine the risk factors for ARF and point out the prognostic factors for mortality in these patients.ResultsA total of 1732 patients were evaluated, with an ARF prevalence of 57%. Of the 889 patients who were admitted without ARF, 141 (16%) developed this syndrome in the ICU. The independent risk factors for developing ARF were 64 years of age or older, longer time between hospital and ICU admission, unscheduled surgical or clinical reason for ICU admission, and severity of illness. Of the 984 patients with ARF, 475 (48%) died during the ICU stay. Independent prognostic factors for death were age older than 64 years, time between hospital and ICU admission of more than 4 days, history of hematologic malignancy or AIDS, the development of ARF in ICU, acute lung injury, and severity of illness.ConclusionsAcute respiratory failure represents a large percentage of all ICU patients, and the high mortality is related to some preventable factors such as the time to ICU admission.Copyright © 2011 Elsevier Inc. All rights reserved.

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