• Zhonghua nei ke za zhi · Jul 2011

    Clinical Trial

    [The clinical application of pulmonary vascular permeability index on differential diagnosis of acute pulmonary edema].

    • Cong-shan Yang, Jian-feng Xie, Min Mo, Song-qiao Liu, Ying-zi Huang, Hai-bo Qiu, and Yi Yang.
    • Department of Critical Care Medicine, Nanjing Zhongda Hospital, Southeast University, Nanjing 210009, China.
    • Zhonghua Nei Ke Za Zhi. 2011 Jul 1;50(7):593-6.

    ObjectiveTo assess the value of pulmonary vascular permeability index in differentiating acute lung injury (ALI) from cardiac pulmonary edema.MethodsCritically ill patients with acute pulmonary edema were included from May, 2004 to September, 2008. Patients were divided into two groups, the ALI group and the cardiac pulmonary edema group (C group). Pulmonary vascular permeability index (PVPI), intrathoracic blood volume (ITBVI) were determined by pulse indicator continuous cardiac output (PiCCO) system.Results(1) Thirty-four patients were enrolled, 22 cases in ALI group and 12 cases in C group. (2) The PVPI in patients of ALI group (2.7 ± 1.4) was higher than that of C group (1.9 ± 0.6; P < 0.05). EVLWI and ITBVI did not have the significant difference between the two groups (P > 0.05). (3) PVPI was positively correlated with EVLWI (r = 0.762), negatively correlated with PaO2/FiO2 (r = -0.478). (4) ARDS was diagnosed in 13 cases, including 8 pulmonary cause (ARDSp) and 5 extra-pulmonary cause (ARDSexp). PVPI, EVLW/ITBV and EVLWI of patients with ARDSexp were obviously higher than those with ARDSp.ConclusionsPVPI may be useful for differentiating the types of pulmonary edema in the critically ill.

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