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Int. Arch. Allergy Immunol. · Jan 2006
Case ReportsDrug Rash with eosinophilia and systemic symptoms versus Stevens-Johnson Syndrome--a case that indicates a stumbling block in the current classification.
- Ronni Wolf, Batya Davidovici, Hagit Matz, Keren Mahlab, Edith Orion, and Zev M Sthoeger.
- Dermatology Unit, Kaplan Medical Center, Rechovot, Israel. wolf_r@netvision.net.il
- Int. Arch. Allergy Immunol. 2006 Jan 1;141(3):308-10.
AbstractA 43-year-old man developed a skin eruption characterized by 'macules with blisters' typical to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks after he had started treatment with lamotrigine. He had a fever (39.6 degrees C), elevated liver enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs. A case that precisely fits the definition of two syndromes that have different characteristics, different treatments and different prognoses indicates that there is a flaw in the classification.
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