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Br J Oral Maxillofac Surg · Jun 2003
Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats.
- L Rasubala, H Yoshikawa, K Nagata, T Iijima, and M Ohishi.
- Department of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. rasubala@isc.kyushu-u.ac.jp
- Br J Oral Maxillofac Surg. 2003 Jun 1;41(3):173-8.
AbstractWe studied the effects of platelet-derived growth factor-B (PDGF-B) and bone morphogenetic protein-2 (BMP-2) during the healing of mandibular closed fractures in rats by immunohistochemical methods. Unilateral closed fractures were created in the mandibles of thirty 12-week-old rats. BMP-2 was expressed during all stages of healing, but PDGF-B was expressed mainly in the early and middle stages, and not in the later stage of the healing process. We conclude that PDGF-B was associated with the proliferation and migration of primitive mesenchymal cells. BMP-2 was related to the differentiation of mesenchymal cells into osteoblasts and chondroblasts. PDGF-B and BMP-2 both have distinct regulatory effects on the healing of fractures.
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