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Br J Oral Maxillofac Surg · Aug 2004
Comparative StudyComparison of the healing process in plated and non-plated fractures of the mandible in rats.
- L Rasubala, H Yoshikawa, A A S Islam, K Nagata, T Iijima, and M Ohishi.
- Department of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan. rasubala@bioreg.kyushu-u.ac.jp
- Br J Oral Maxillofac Surg. 2004 Aug 1;42(4):315-22.
AbstractWe compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n = 36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.
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