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Multicenter Study Comparative Study
Pleurodesis outcome in malignant pleural mesothelioma.
- Edward Thomas Hamilton Fysh, Sze Khen Tan, Catherine Ann Read, Felicity Lee, Kate McKenzie, Nola Olsen, Indunil Weerasena, Timothy Threlfall, Nicholas de Klerk, A William Musk, and Y C Gary Lee.
- Respiratory Department, Sir Charles Gairdner Hospital, Perth, Australia.
- Thorax. 2013 Jun 1;68(6):594-6.
AbstractFew data exist on the pleurodesis outcome in patients with malignant pleural mesothelioma (MPM). A retrospective review of the Western Australian Mesothelioma Registry over 5 years revealed 390 evaluable patients. Only a subset of patients (42.3%) underwent pleurodesis, surgically (n=78) or by bedside instillation of sclerosants (n=87). Surgical pleurodesis showed no advantages over bedside pleurodesis in efficacy (32% vs 31% failures requiring further drainage, p=0.98), patient survival (p=0.52) or total time spent in hospital from procedure till death (p=0.36). No clinical, biochemical or radiographic parameters tested adequately predict pleurodesis outcome.
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