• Gabriele Schulz, Markus Weiss, Urs Bauersfeld, Jan Teller, Daniel Haensse, Hans Ulrich Bucher, and Oskar Baenziger.
• Clinic of Neonatology, University Hospital, Rämistrasse 100, 8091 Zurich, Switzerland.
• Intensive Care Med. 2002 Feb 1;28(2):184-9.

ObjectiveTo evaluate the clinical usefulness of near-infrared spatially resolved spectroscopic quantitative assessment of liver tissue oxygenation for simple, non-invasive estimation of global tissue oxygenation in critically ill neonates and children.DesignProspective observational clinical study.SettingA tertiary multidisciplinary neonatal and paediatric intensive care unit (23 beds).PatientsOne hundred neonates and children consecutively admitted to the paediatric intensive care unit.Measurements And ResultsNear-infrared spectroscopic single-point assessment of liver tissue oxygenation index (TOI(Liver)) was compared with global tissue oxygenation as measured by central venous oxygen saturation (SvO(2)) and derived haemodynamic parameters. Data were compared using linear and multiple regression analysis. Overall correlation between TOI(Liver)and SvO(2) was good ( r=0.72, p<0.0001). Multivariable regression revealed that SvO(2) alone explained 51% of the observed variance of TOI(Liver). However, our data demonstrated large inter-individual differences between SvO(2) and TOI(Liver) values.ConclusionNear-infrared spatially resolved spectroscopic quantitative measurement of liver tissue oxygenation correlates well with SvO(2) in critically ill neonates and children. Large inter-individual SvO(2) to TOI(Liver) differences may prevent its use for non-invasive single-point estimation of global tissue oxygenation. Further clinical studies are required to validate the method with other regional and global haemodynamic parameters and to evaluate its clinical use for continuous non-invasive haemodynamic monitoring.

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