• Marcondes C França, Anelyssa D'Abreu, Verônica A Zanardi, Andréia V Faria, Iscia Lopes-Cendes, Anamarli Nucci, and Fernando Cendes.
• Department of Neurology, Campinas State University (UNICAMP), Campinas, Brazil.
• J Neuroimaging. 2008 Apr 1; 18 (2): 168-72.

Background And PurposeSensory neuronopathies (SN) represent a specific subgroup of peripheral nervous system diseases, characterized by degeneration of dorsal root ganglia (DRG) and its projections. We tried to estimate the frequency and extent of spinal cord MRI abnormalities in a group of patients with SN and correlate these with clinical and neurophysiological features.MethodsWe performed spinal cord MRI scans in 16 chronic SN patients. Images were analyzed for the presence of posterior hyperintense lesions on T2WI and cord areas at C3 level were obtained using a previously validated method. A group of 14 healthy controls with similar age and gender distribution was used for comparison. ANOVA was employed for statistical analysis.ResultsPosterior T2WI lesions were found in 13 out of 16 patients. Cord areas were significantly smaller in SN patients than controls (84.3 x 97.2 mm(2), P < .05). Atrophy correlated with severity of sensory ataxia and neurophysiologic abnormalities but not with duration of disease.ConclusionsThese findings support volumetric spinal cord MRI as a useful tool in the assessment of chronic SN.

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