• J Neuroimaging · Oct 2010

    Case Reports

    Brainstem involvement in Sjögren's syndrome-related sensory neuronopathy.

    • Alfredo Damasceno, Marcondes C França, Verônica A Zanardi, and Anamarli Nucci.
    • Departments of Neurology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil. alfredodamasceno@hotmail.com
    • J Neuroimaging. 2010 Oct 1;20(4):397-9.

    Background And PurposeSensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Magnetic resonance imaging (MRI) studies have shown abnormalities limited to T2-weighted high signal intensity in the posterior columns.Methods And ResultsA 65-year-old woman with Sjögren syndrome had slowly progressive unsteadiness of gait and limb paresthesias. A blink reflex examination suggested a paramedian brainstem lesion, confirmed by MRI.ConclusionsSjögren's syndrome-related SN may be associated with a more diffuse immune-mediated aggression, involving also the brainstem, and leading to some of the blink reflex abnormalities observed in nonparaneoplastic SN.Copyright © 2009 by the American Society of Neuroimaging.

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