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- Emi Noguchi and Chikako Shimizu.
- Division of Breast and Medical Oncology, National Cancer Center Hospital, Japan.
- Gan To Kagaku Ryoho. 2013 Jan 1;40(1):10-4.
AbstractHER2-targeted therapy for HER2-positive breast cancer is one of the success stories in medical oncology. Trastuzumab, a humanized monoclonal antibody, was the first approved HER2-targeted agent. Subsequent developments include agents with different mechanisms, such as lapatinib, a tyrosine kinase inhibitor. We describe here the results of late-phase clinical trials of two newly-available anti-HER2 agents, T-DM1 and pertuzumab.
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