• Gen Hosp Psychiatry · Mar 2010

    Randomized Controlled Trial

    Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome.

    • Ramona O Hopkins, Colin W Key, Mary R Suchyta, Lindell K Weaver, and James F Orme.
    • Pulmonary and Critical Care Division, Department of Medicine, LDS Hospital, Salt Lake City, UT 84107, USA. ramona.hopkins@imail.org
    • Gen Hosp Psychiatry. 2010 Mar 1;32(2):147-55.

    ObjectiveDepression and anxiety are common morbidities of critical illness. We assessed risk factors of depression and anxiety in Acute Respiratory Distress Syndrome (ARDS) survivors at 1 and 2 years post-hospital discharge.MethodRisk factors for depression and anxiety at 1 and 2 years were assessed using stepwise multiple regression analyses, with and without 1-year outcomes.ResultsARDS survivors had depression (16% and 23%) and anxiety (24% and 23%) at 1 and 2 years, respectively. Predictors of depression at 1 year were alcohol dependence, female gender and younger age (P=.006). Predictors of anxiety were ratio of arterial oxygen tension to inspired oxygen fraction and duration of mechanical ventilation (P<.005). Predictors of depression at 2 years were depression at 1 year and the presence of cognitive sequelae (P<.0001). Predictors of anxiety at 2 years was anxiety at 1 year (P<.0001).ConclusionsMedical variables that predicted depression or anxiety at 1 year no longer predicted depression and anxiety at 2 years. Medical variables appear to have a short-term effect on psychiatric outcomes. At 2 years lifestyle behaviors including history of smoking along with cognitive sequelae, depression and anxiety at 1 year predict depression and anxiety.Copyright 2010 Elsevier Inc. All rights reserved.

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