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Best Pract Res Clin Rheumatol · Jun 2007
ReviewPharmacological treatment of fibromyalgia and other chronic musculoskeletal pain.
- Don L Goldenberg.
- Newton-Wellesley Hospital, Division of Rheumatology, Newton, MA 02468, USA. dgoldenb@massmed.org
- Best Pract Res Clin Rheumatol. 2007 Jun 1;21(3):499-511.
AbstractThe pharmacologic management of fibromyalgia is based on the emerging evidence that pain in this disorder is primarily related to central pain sensitization. There is strong evidence that tricyclic antidepressants are effective, and moderate evidence for the effectiveness of serotonin reuptake inhibitors and dual serotonin-norepinephrine reuptake inhibitors. Recent work suggests that the anti-seizure medications pregabalin and gabepentin are also effective. The only analgesic demonstrated to be helpful is tramadol.
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