• J Invasive Cardiol · Jul 2011

    Case Reports

    Subacute stent thrombosis owing to complete clopidogrel resistance successfully managed with prasugrel.

    • Michael P Flaherty, Peter V Johnston, and Jeffrey J Rade.
    • Division of Cardiovascular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.
    • J Invasive Cardiol. 2011 Jul 1;23(7):300-4.

    AbstractThis report describes a case of an acute anterior myocardial infarction secondary to subacute stent thrombosis of a drug-eluting stent within the proximal segment of the left anterior descending artery (LAD) 5 days after percutaneous transluminal coronary angioplasty and stenting (PCI). The patient was initially managed with conventional dual-antiplatelet therapy (aspirin and clopidogrel) and was subsequently found to have complete absence of adenosine diphosphate (ADP) receptor P2Y12 receptor inhibition. Following additional PCI of the LAD and substitution of clopidogrel for the thienopyridine prasugrel, therapeutic platelet inhibition was achieved without recurrence of stent thrombosis.

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