• Journal of anesthesia · Apr 2016

    Case Reports

    Dexmedetomidine-related polyuria in a pediatric patient.

    • Phillip S Adams and Antonio Cassara.
    • Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA, 15224, USA. adamsp@upmc.edu.
    • J Anesth. 2016 Apr 1; 30 (2): 352-5.

    AbstractPolyuria related to pharmacologic α2-adrenoreceptor agonism has been well described in vitro and in animal models and is thought to be the result of functional antagonism of arginine vasopressin. Despite its widespread use as a sedative and anesthetic adjunct, very few reports of dexmedetomidine-related polyuria in humans exist in the literature. We present the first description of a pediatric patient manifesting polyuria and hypernatremia in association with dexmedetomidine infusion for posterior spinal fusion.

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