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Obstetrics and gynecology · May 1997
Case ReportsUterine rupture during induction of labor at term with intravaginal misoprostol.
- B B Bennett.
- Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, USA.
- Obstet Gynecol. 1997 May 1;89(5 Pt 2):832-3.
BackgroundMisoprostol (prostaglandin E1) compares favorably with dinoprostone (prostaglandin E2) and oxytocin for labor induction at term. Excessive uterine activity has been reported using high-dose regimens, but no negative effect on outcomes has been observed.CaseLabor was induced in a 34-year-old multipara at 39 weeks' gestation using intravaginal misoprostol tablets. Five hours after administration of the second 25-microgram dose, fetal bradycardia prompted emergency cesarean delivery. Hysterectomy and left salpingo-oophorectomy were necessary to control bleeding from a 15-cm posterior uterine wall rupture.ConclusionMisoprostol can cause excessive uterine activity and uterine rupture.
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