• Christopher E Clark, Rod S Taylor, Angela C Shore, and John L Campbell.
• Primary Care Research Group, Institute of Health Services Research, Peninsula College of Medicine and Dentistry, University of Exeter, Devon EX1 2LU, UK. christopher.clark@pms.ac.uk
• BMJ. 2012 Jan 1;344:e1327.

ObjectiveTo determine whether a difference in systolic blood pressure readings between arms can predict a reduced event free survival after 10 years.DesignCohort study.SettingRural general practice in Devon, United Kingdom.Participants230 people receiving treatment for hypertension in primary care.InterventionBilateral blood pressure measurements recorded at three successive surgery attendances.Main Outcome MeasuresCardiovascular events and deaths from all causes during a median follow-up of 9.8 years.ResultsAt recruitment 24% (55/230) of participants had a mean interarm difference in systolic blood pressure of 10 mm Hg or more and 9% (21/230) of 15 mm Hg or more; these differences were associated with an increased risk of all cause mortality (adjusted hazard ratio 3.6, 95% confidence interval 2.0 to 6.5 and 3.1, 1.6 to 6.0, respectively). The risk of death was also increased in 183 participants without pre-existing cardiovascular disease with an interarm difference in systolic blood pressure of 10 mm Hg or more or 15 mm Hg or more (2.6, 1.4 to 4.8 and 2.7, 1.3 to 5.4). An interarm difference in diastolic blood pressure of 10 mm Hg or more was weakly associated with an increased risk of cardiovascular events or death.ConclusionsDifferences in systolic blood pressure between arms can predict an increased risk of cardiovascular events and all cause mortality over 10 years in people with hypertension. This difference could be a valuable indicator of increased cardiovascular risk. Bilateral blood pressure measurements should become a routine part of cardiovascular assessment in primary care.

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