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Obstetrics and gynecology · Mar 2005
Case ReportsHerceptin (trastuzumab) therapy during pregnancy: association with reversible anhydramnios.
- William J Watson.
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. Watson.William@mayo.edu
- Obstet Gynecol. 2005 Mar 1;105(3):642-3.
BackgroundHerceptin (trastuzumab), a new a chemotherapeutic agent, is a monoclonal antibody that blocks the human epidermal growth factor receptor 2 protein. There is no reported experience with use of this agent during pregnancy and possible effects on the fetus.CaseA patient with breast cancer was treated with Herceptin during pregnancy. This treatment was associated with anhydramnios, which resolved slowly after the drug was discontinued.ConclusionAlthough listed as a category B drug, experience with Herceptin in human pregnancy is limited, and it should be used with caution. Investigation of the role of human epidermal growth factor receptor 2 protein in the embryonic kidney may further our understanding of amniotic fluid dynamics.
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