• Clin Obstet Gynecol · Dec 2014

    Review

    Severe sepsis during pregnancy.

    • Luis D Pacheco, George R Saade, and Gary D V Hankins.
    • *Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine †Department of Anesthesiology, Division of Surgical Critical Care, The University of Texas Medical Branch at Galveston, Galveston, Texas.
    • Clin Obstet Gynecol. 2014 Dec 1;57(4):827-34.

    AbstractSevere sepsis is a major cause of mortality among critically ill patients. Early recognition accompanied by early initiation of broad-spectrum antibiotics with source control and fluid resuscitation improves outcomes. Hemodynamic resuscitation starts with fluid therapy followed by vasopressors if necessary. Cases refractory to first-line vasopressors (norepinephrine) will require second-line vasopressors (epinephrine or vasopressin) and low-dose steroid therapy. Resuscitation goals should include optimization of central venous oxygenation and serum lactate.

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