• Med. J. Malaysia · Dec 2008

    Randomized Controlled Trial

    Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine.

    • N Ahmad, Y Zanariah, and S Balan.
    • Department of Anaesthesiology & Intensive Care, Hospital Sultanah Aminah, Jalan Abu Bakar, Johor Bahru, Johor, Malaysia. irenelooi@yahoo.com
    • Med. J. Malaysia. 2008 Dec 1;63(5):431-3.

    AbstractWe studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro. One hundred and seventy patients were randomly allocated to receive either 100 mcg of intravenous fentanyl or normal saline (placebo) followed by intravenous Propofol-Lipuro premixed with 20 mg lignocaine. The incidence of injection pain was 32% and 13% in the placebo and fentanyl groups, respectively. We found a statistically significant reduction in incidence of injection pain in the fentanyl group when compared with the placebo group (p<0.003). The number needed to treat was 6 (3.2< 95% CI <15.1). In conclusion, fentanyl pretreatment is effective in alleviating pain during injection of Propofol-Lipuro.

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