• Zhongguo Fei Ai Za Zhi · Mar 2009

    [Distribution and mRNA Expression of BAMBI in Non-small-cell Lung Cancer.].

    • Shen Miao, Lei Zhao, Jian Gao, Hui Wang, and Zeshi Cui.
    • Center of Laboratory Technology and Experimental Medicine, China Medical University, Shenyang 110001, China.
    • Zhongguo Fei Ai Za Zhi. 2009 Mar 20;12(3):203-7.

    BackgroundBAMBI structure is similar with that of the receptor I of TGF-beta, it broadly participates in the control of TGF-beta signaling. The aim of this study is to investigate the expression and its significance of BAMBI in non-small cell lung cancer (NSCLC) and explore the relation between BAMBI and clinical and pathological factors of NSCLC.MethodsSixty-three cases with NSCLC and adjacent normal tissue specimens were used for immunohistochemical assay. Thirty-one fresh lung cancer tissue specimens and surrounding normal lung tissue specimens was preserved for RT-PCR in -70 (o)C after quick-frozen in liquid nitrogen immediately.ResultsThe level of BAMBI mRNA in cancer tissues was higher than that in the corresponding adjacent tissues (0.358+/-0.135 vs 0.249+/-0.129), with the difference being statistically significant (P =0.003). BAMBI protein expressed mainly in the membrane and the cytoplasm close to the membrane, its expression in the cancer tissue was higher than that in the adjacent tissues, the difference was significant (P <0.01). Expression of BAMBI in the cancer tissue was higher than that in the adjacent tissues, and the expression of BAMBI in adenocarcinoma of lung is higher than that in squamous carcinoma.ConclusionsThe expressions of BAMBI significantly increase in NSCLC. It might be a common affair in carcinogenesis of NSCLC.

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