• Elizabeth Maccariello, Eduardo Rocha, Carla Valente, Lina Nogueira, Pedro T Rocha, Hélio Bonomo, Luciana F Serpa, Márcia Ismael, Ricardo V R Valença, José E S Machado, and Márcio Soares.
• D'Or de Hospitais, Rio de Janeiro, Brazil. emaccariello@yahoo.com.br
• Clinics (Sao Paulo). 2008 Jun 1;63(3):343-50.

IntroductionAcute kidney injury usually develops in critically ill patients in the context of multiple organ dysfunctions.ObjectiveTo evaluate the effect of changes in associated organ dysfunctions over the first three days of renal replacement therapy on the outcomes of patients with acute kidney injury.MethodsOver a 19-month period, we evaluated 260 patients admitted to the intensive care units of three tertiary-care hospitals who required renal replacement therapy for > 48 h. Organ dysfunctions were evaluated by SOFA score (excluding renal points) on the first (D1) and third (D3) days of renal replacement therapy. Absolute (A-SOFA) and relative (Delta-SOFA) changes in SOFA scores were also calculated.ResultsHospital mortality rate was 75%. Organ dysfunctions worsened (A-SOFA>0) in 53%, remained unchanged (A-SOFA=0) in 17% and improved (A-SOFA<0) in 30% of patients; and mortality was lower in the last group (80% vs. 84% vs. 61%, p=0.003). SOFA on D1 (p<0.001), SOFA on D3 (p<0.001), A-SOFA (p=0.019) and Delta-SOFA (p=0.016) were higher in non-survivors. However, neither A-SOFA nor Delta-SOFA discriminated survivors from non-survivors on an individual basis. Adjusting for other covariates (including SOFA on D1), A-SOFA and Delta-SOFA were associated with increased mortality, and patients in whom SOFA scores worsened or remained unchanged had poorer outcomes.ConclusionsIn addition to baseline values, early changes in SOFA score after the start of renal replacement therapy were associated with hospital mortality. However, no prognostic score should be used as the only parameter to predict individual outcomes.

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