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Case Reports
Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation.
- Daniel N Holena, Nikolai S Tolstoy, Angela M Mills, Adam D Fox, and Joshua M Levine.
- Department of Trauma and Surgical Critical Care, Hospital of the University of Pennsylvania, Philadelphia, USA.
- Am. J. Crit. Care. 2012 Jan 1;21(1):72-5.
AbstractA comatose 23-year-old woman with acute liver failure due to an overdose of acetaminophen had indications of intracranial hypertension and underwent liver transplantation. Her level of arousal did not improve, and on postoperative day 1, clinical signs of cerebral herniation became apparent. An intracranial pressure monitor was placed, and intracranial hypertension was documented. Elevations in intracranial pressure persisted despite maximal osmotherapy, and therapeutic hypothermia was started. Normalization of intracranial pressure was rapid. Findings on neurological examination improved and the patient was discharged from the hospital with no neurological impairment.
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