• Anne de-Wahl Granelli, Margareta Wennergren, Kenneth Sandberg, Mats Mellander, Carina Bejlum, Leif Inganäs, Monica Eriksson, Niklas Segerdahl, Annelie Agren, Britt-Marie Ekman-Joelsson, Jan Sunnegårdh, Mario Verdicchio, and Ingegerd Ostman-Smith.
• Department of Paediatric Cardiology, Queen Silvia Children's Hospital, S-416 85 Göteborg, Sweden.
• BMJ. 2009 Jan 1;338:a3037.

ObjectiveTo evaluate the use of pulse oximetry to screen for early detection of life threatening congenital heart disease.DesignProspective screening study with a new generation pulse oximeter before discharge from well baby nurseries in West Götaland. Cohort study comparing the detection rate of duct dependent circulation in West Götaland with that in other regions not using pulse oximetry screening. Deaths at home with undetected duct dependent circulation were included.SettingAll 5 maternity units in West Götaland and the supraregional referral centre for neonatal cardiac surgery.Participants39,821 screened babies born between 1 July 2004 and 31 March 2007. Total duct dependent circulation cohorts: West Götaland n=60, other referring regions n=100.Main Outcome MeasuresSensitivity, specificity, positive and negative predictive values, and likelihood ratio for pulse oximetry screening and for neonatal physical examination alone.ResultsIn West Götaland 29 babies in well baby nurseries had duct dependent circulation undetected before neonatal discharge examination. In 13 cases, pulse oximetry showed oxygen saturations ConclusionIntroducing pulse oximetry screening before discharge improved total detection rate of duct dependent circulation to 92%. Such screening seems cost neutral in the short term, but the probable prevention of neurological morbidity and reduced need for preoperative neonatal intensive care suggest that such screening will be cost effective long term.

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