• J Arthroplasty · Aug 2014

    Randomized Controlled Trial Comparative Study

    Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty.

    • Ashwani Soni, Raghav Saini, Anmol Gulati, Rajesh Paul, Shiraj Bhatty, and Sreekanth Reddy Rajoli.
    • Department of Orthopaedics, GGS Medical College and Hospital, Faridkot, India.
    • J Arthroplasty. 2014 Aug 1;29(8):1525-7.

    AbstractTranexamic acid is an antifibrinolytic drug used widely to prevent bleeding. Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic acid during the total knee arthroplasty surgery. A total of 40 patients were received three doses of intravenous tranexamic acid during total knee arthroplasty surgery. Intra-articular tranexamic acid was used in 40 patients during the surgery. We concluded that intra-articular tranexamic acid is equally effective as three dose intravenous regimen in reducing blood loss during total knee arthroplasty surgery.Copyright © 2014 Elsevier Inc. All rights reserved.

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