• Melody Y Hou, Shelley Hurwitz, Erin Kavanagh, Jennifer Fortin, and Alisa B Goldberg.
• Boston University School of Medicine, Boston, Massachusetts, USA. Melody.hou@bmc.org
• Obstet Gynecol. 2010 Sep 1;116(3):633-40.

ObjectiveTo estimate whether women receiving daily text-message reminders have increased oral contraceptive pill adherence compared with women not receiving reminders.MethodsThis randomized controlled trial estimated whether there was an effect of daily text-message reminders on oral contraceptive pill adherence of new oral contraceptive pill users. Pill-taking was tracked for 3 months by an electronic monitoring device with wireless data collection. During the study period, participants assigned the intervention received a daily reminder text message. Eighty-two women were assigned randomly to detect a 1.6+/-2.0 pill difference (90% power, 5% alpha, 15% dropout).ResultsParticipants were 79% white, non-Hispanic, 99% high school graduates, and 99% nulliparous with a mean age of 22 years. Most reported condom use with past coital activity, and more than half reported prior emergency contraception use. The mean number of missed pills per cycle did not differ significantly between the groups: 4.9+/-3.0 for the text-message group and 4.6+/-3.5 for the control group (P=.60). The number of missed pills per cycle increased over the course of the study, but this pattern did not increase differentially between the groups. Adherence recorded by the electronic monitoring device indicated much poorer adherence than that recorded by patient diaries. Despite poor pill-taking, there were no pregnancies.ConclusionDaily text-message reminders did not improve oral contraceptive pill adherence. Although the lack of benefit may be attributed to the frequent use of alternative reminder systems in the control group, the rate of missed pills when measured objectively was still very high in both groups.Clinical Trial RegistrationClinicaltrials.gov, www.clinicaltrials.gov, NCT00733707.Level Of EvidenceI.

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