• Kiyoshi Nagase and Hiroki Iida.
• Operation Division, Gifu University Hospital, Gifu 501-1194.
• Masui. 2012 Mar 1;61(3):292-8.

BackgroundIt is recommended to minimize neuromuscular blocker administration during general anesthesia for the efficacy of operating room utilization and potential hazards of unintended awareness during anesthesia.MethodsWe retrospectively compared the dose of vecuronium in consecutive 8,007 patients under general anesthesia receiving remifentanil or fentanyl. In analyzing electronic anesthesia records over 4 years in a single university institute, we also examined the type of general anesthesia and the required time of each pro- cedure in the operating room.ResultsLess vecuronium was necessary in patients administered remifentanil than those given fentanyl both maintained with inhalational and intravenous anesthesia. Supplementation with epidural anesthesia did not influence the dose of vecuronium in patients under general anesthesia receiving remifentanil or fentanyl. We also measured the time necessary before extubating trachea after finishing surgery, while no difference was found between the patients recieving remifentanil and fentanyl.ConclusionsAnesthesia with remifentanil reduces requirement of vecuronium dose greater than with fentanyl, while it does not affect the emergence time from anesthesia.

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