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- Aparajita Sohoni, Colin Feeney, Larry Lambert, and Robert McCabe.
- Department of Emergency Medicine, Alameda County Medical Center, Oakland, California 94602, USA.
- Am. J. Crit. Care. 2013 Jul 1;22(4):364-7.
AbstractCommunity-associated methicillin-resistant Staphylococcus aureus is a frequent cause of skin and soft-tissue infections and is increasingly identified as a cause of pneumonia in immunocompetent patients. Panton-Valentine leukocidin, one of several leukocytotoxic peptides secreted by these cocci, is associated with increased virulence. A cluster of 3 unrelated patients with fatal pneumonia presumably caused by community-associated methicillin-resistant S aureus positive for Panton-Valentine leukocidin were treated in a 3-week period. Despite aggressive care and appropriate, timely administration of antibiotics, all 3 patients died. This article reviews the clinical and laboratory features suggestive of this lethal isolate, including unique findings on Gram stains of sputum.
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